This is probably all over the web now, but if anyone still hasn’t run across this — well worth watching not only the YouTube excerpt but the long version. (CMU site seems overloaded — this is an alternative source for the long version.)
I saw him give some parts of this, where he talked about his work over the years, at CHI in Portland a few years ago. He was then, and is now, fascinating — a terrific speaker, doing fascinating work, and reflecting on it. He’s now dying of pancreatic cancer at age 46, and this was his last lecture: on what he’s done, what he’s learned.
He says he’s had fun every day of his life and plans to continue to. I believe it.